Pierre-Emile Hojbjerg said Tottenham went down with "the flag held high" in their 4-1 loss to Chelsea and has backed the squad to cope with the absence of key personnel.

Spurs lost their unbeaten start to the Premier League season in a pulsating London derby in which five goals were disallowed and the hosts played the final 35 minutes with nine men.

To add salt into fresh Tottenham wounds, Micky van de Ven was forced off with a hamstring injury and James Maddison had to be withdrawn due to an ankle knock, while Cristian Romero and Destiny Udogie, who were both sent off, will sit out this weekend's trip to Wolves.

Ange Postecoglou's side battled admirably, first with 10 men from the 35th minute and then when down to nine early in the second half, but Nicolas Jackson grabbed the first of his three goals with quarter of an hour left to finally break the hosts' resolve.

Hojbjerg said: "I think we went down with the flag held high. We gave it our all but the result hurts a lot.

"We showed what we had in our hearts but the result hurts.

"Tuesday we have a day off and when we see each other on Wednesday, we'll gather the pieces and focus on the next game, as we have to.

"Everyone has to show their availability and show they are prepared to do what it takes.

"A good squad is not 11 players. It is 18 or 25 players and this is what we have to show. The result hurts a lot but we have to keep going."

Mauricio Pochettino's first return to Tottenham had initially started in the worst possible fashion when Dejan Kulusevski's curled effort deflected off Levi Colwill and beyond the helpless Robert Sanchez after six minutes.

The wheels started to fall off during a 57-minute first half where four goals were chalked off by video assistant referee John Brooks at Stockley Park, who decided that Romero's tackle on Enzo Fernandez was worthy of a red card and a penalty in the 33rd minute.

Spurs' uphill task increased further when Udogie was shown a second yellow after 10 minutes of the second period, but Postecoglou deployed a high line and Guglielmo Vicario starred in the sweeper-keeper role before Jackson made it 2-1.

Tottenham remained resolute and started to create chances with substitute Eric Dier marginally offside when he volleyed home soon after Jackson's first goal before Rodrigo Bentancur and Son Heung-min squandered opportunities.

Jackson made the points safe in stoppage time when he lashed in from Conor Gallagher's pass, but Spurs supporters greeted the goal with a standing ovation for their crestfallen players.

Kulusevski said: "It was unbelievable, honestly. Some things are bigger than life, bigger than football, bigger than the wins.

"Honestly I was really proud of that moment and the fans. I was grateful and it makes me want to give more back.

"It has to give us fuel. We lost the game, we hate to lose, it was the first of the season, but we have to make sure this doesn't happen again and play 11 v 11 because then it is much harder to beat us."

The consequences of this defeat could be long-lasting with Romero set for a three-match ban, which will rule him out of matches with Wolves, Aston Villa and Manchester City.

Of bigger concern is centre-back partner Van de Ven after he pulled up at the end of the first half in a sprint with Jackson, which saw him helped off the pitch and he was later seen on crutches.

Udogie will also miss Saturday's clash at Wolves and with Ben Davies nursing an ankle knock, Postecoglou could use Under-21 defenders Ash Phillips or Alfie Dorrington this weekend.

"It will be a test for sure. They (Van de Ven and Maddison) are amazing players and I hope they are back very, very soon, but as you saw the players that came in were amazing," Kulusevski said.

"We train really hard every day and everybody is ready. You saw Eric Dier, he came in, did his first appearance and was unbelievable. The guys are ready.

"Everybody wants to play and it is so high level the training. So, if (Phillips) will be called, he will be ready."

*copy from Press Association.